Gene

tp53bp2b

ID

ZDB-GENE-050208-453

Name

tumor protein p53 binding protein, 2b

Symbol

tp53bp2b Nomenclature History

Previous Names

aspp2b (1)
si:dkeyp-34c12.2

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have p53 binding activity. Involved in chordate embryonic development; cilium movement; and negative regulation of protein kinase B signaling. Localizes to cytoplasm. Is expressed in several structures, including gill; heart; liver; muscle; and pleuroperitoneal region. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Choksi et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tp53bp2b Human Ortholog

No data available

Associated With tp53bp2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000159	Ras-associating domain
Domain	IPR001452	SH3 domain
Domain	IPR048945	Ras association domain-containing protein 8/10, RA domain
Family	IPR047163	Apoptosis-stimulating of p53 protein 1/2
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Apoptosis-stimulating of p53 protein 1/2	Ras-associating domain	Ras association domain-containing protein 8/10, RA domain	SH3 domain	SH3-like domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:F1QWN1 InterPro	1063
UniProtKB:A0A8M3AUV3 InterPro	1062
UniProtKB:Q1LXN7 InterPro	1060

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tp53bp2b-201 (1) Ensembl	Ensembl	4,255 nt	Select Tool ZFIN BLAST
mRNA	tp53bp2b-202 (1) Ensembl	Ensembl	3,187 nt	Select Tool
mRNA	tp53bp2b-203 (1) Ensembl	Ensembl	4,175 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations