Gene
loxl2b
- ID
- ZDB-GENE-050208-29
- Name
- lysyl oxidase-like 2b
- Symbol
- loxl2b Nomenclature History
- Previous Names
-
- im:7136137
- si:dkeyp-32b1.1
- wu:fk12g04
- zgc:158414
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; copper ion binding activity; and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; peptidyl-lysine oxidation; and positive regulation of cell differentiation. Predicted to act upstream of or within chromatin organization. Predicted to be located in several cellular components, including basement membrane; chromatin; and endoplasmic reticulum. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in diencephalon; head mesenchyme; hindbrain; notochord; and pectoral fin. Orthologous to human LOXL2 (lysyl oxidase like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136137 (7 images)
- IMAGE:7156383 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gansner et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Lysyl oxidase | Lysyl oxidase, conserved site | Lysyl oxidase-like protein | SRCR domain | SRCR-like domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A1L1V4
|
762 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
loxl2b-201
(1)
|
Ensembl | 4,613 nt | ||
| mRNA |
loxl2b-202
(1)
|
Ensembl | 3,555 nt | ||
| mRNA |
loxl2b-203
(1)
|
Ensembl | 6,171 nt | ||
| mRNA |
loxl2b-204
(1)
|
Ensembl | 4,884 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-202K21 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-32B1 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-38H2 | ZFIN Curated Data | |
| Encodes | EST | fk12g04 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7136137 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7156383 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:158414 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174590 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080626 (1) | 2950 nt | ||
| Genomic | GenBank:BX323062 (1) | 199133 nt | ||
| Polypeptide | UniProtKB:A1L1V4 (1) | 762 aa |
- Allanki, S., Strilic, B., Scheinberger, L., Onderwater, Y.L., Marks, A., Günther, S., Preussner, J., Kikhi, K., Looso, M., Stainier, D.Y.R., Reischauer, S. (2021) Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. Science advances. 7:eabg6497
- Huang, V., Butler, A.A., Lubin, F.D. (2019) Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Scientific Reports. 9:1379
- Maheras, A.L., Dix, B., Carmo, O.M.S., Young, A.E., Gill, V.N., Sun, J.L., Booker, A.R., Thomason, H.A., Ibrahim, A.E., Stanislaw, L., Dallego, J.C., Ngo, C.N., Chen, A., Fortini, B.K., Spence, R.D. (2018) Genetic Pathways of Neuroregeneration in a Novel Mild Traumatic Brain Injury Model in Adult Zebrafish. eNeuro. 5(1)
- Cao, J., Navis, A., Cox, B.D., Dickson, A.L., Gemberling, M., Karra, R., Bagnat, M., Poss, K.D. (2016) Single epicardial cell transcriptome sequencing identifies Caveolin-1 as an essential factor in zebrafish heart regeneration. Development (Cambridge, England). 143(2):232-43
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Iturbide, A., Pascual-Reguant, L., Fargas, L., Cebrià, J.P., Alsina, B., García de Herreros, A., Peiró, S. (2015) LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation. Molecular Cell. 58(5):755-66
- Oka, Y., Sato, T.N. (2015) Whole-mount single molecule FISH method for zebrafish embryo. Scientific Reports. 5:8571
- Wotton, K.R., Weierud, F.K., Dietrich, S., and Lewis, K.E. (2008) Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evolutionary Biology. 8:171
- Gansner, J.M., Mendelsohn, B.A., Hultman, K.A., Johnson, S.L., and Gitlin, J.D. (2007) Essential role of lysyl oxidases in notochord development. Developmental Biology. 307(2):202-213
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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