Gene
sorl1
- ID
- ZDB-GENE-050208-22
- Name
- sortilin-related receptor, L(DLR class) A repeats containing
- Symbol
- sorl1 Nomenclature History
- Previous Names
-
- im:7135957
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to be involved in post-Golgi vesicle-mediated transport; protein retention in Golgi apparatus; and protein targeting to lysosome. Predicted to localize to Golgi apparatus and integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in central nervous system; hatching gland; mesoderm; and somite. Orthologous to human SORL1 (sortilin related receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7135957 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR006581 | VPS10 |
| Domain | IPR031777 | Sortilin, C-terminal |
| Domain | IPR031778 | Sortilin, N-terminal |
| Family | IPR050310 | VPS10-related sortilin family receptors |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Repeat | IPR000033 | LDLR class B repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Six-bladed beta-propeller, TolB-like | Sortilin, C-terminal | Sortilin, N-terminal | VPS10 | VPS10-related sortilin family receptors | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B3P2
|
2211 | |||||||||||||
|
UniProtKB:X1WHE3
|
2213 |
Interactions and Pathways
No data available
Plasmids
No data available