Gene

cacnb2b

ID
ZDB-GENE-050208-129
Name
calcium channel, voltage-dependent, beta 2b
Symbol
cacnb2b Nomenclature History
Previous Names
  • CAB2a (1)
  • CACNB2.2 (1)
  • cacnb2a (1)
  • im:7141271
  • si:dkey-32m20.2
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have high voltage-gated calcium channel activity. Predicted to be involved in chemical synaptic transmission; neuromuscular junction development; and regulation of voltage-gated calcium channel activity. Predicted to localize to voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cacnb2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Brugada syndrome 4 Alliance Brugada syndrome 4 611876
Associated With cacnb2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Family IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Domain Details Per Protein
Protein Length Guanylate kinase/L-type calcium channel beta subunit P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily Voltage-dependent calcium channel, L-type, beta subunit
UniProtKB:B2XY80 449
UniProtKB:C9VXY1 439
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cacnb2b-201 (1) Ensembl 1,131 nt
mRNA cacnb2b-202 (1) Ensembl 1,101 nt
mRNA cacnb2b-203 (1) Ensembl 1,897 nt
ncRNA cacnb2b-002 (1) Ensembl 702 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations