Gene
fgf5
- ID
- ZDB-GENE-050201-6
- Name
- fibroblast growth factor 5
- Symbol
- fgf5 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within cranial ganglion development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in anterior lateral line ganglion; hindbrain; kidney; statoacoustic (VIII) ganglion; and trigeminal ganglion. Human ortholog(s) of this gene implicated in familial isolated trichomegaly. Orthologous to human FGF5 (fibroblast growth factor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011204Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa33666 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial isolated trichomegaly | Alliance | Trichomegaly | 190330 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|
|
UniProtKB:Q5TLE2
|
225 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-57H10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194354 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194357 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009561 (1) | 678 nt | ||
| Genomic | GenBank:BX629340 (1) | 172090 nt | ||
| Polypeptide | UniProtKB:Q5TLE2 (1) | 225 aa |
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Shibata, E., Yokota, Y., Horita, N., Kudo, A., Abe, G., Kawakami, K., Kawakami, A. (2016) Fgf signalling controls diverse aspects of fin regeneration. Development (Cambridge, England). 143:2920-9
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Kumar, M., and Chapman, S.C. (2012) Cloning and expression analysis of Fgf5, 6 and 7 during early chick development. Gene expression patterns : GEP. 12(7-8):245-253
- Shin, D., Weidinger, G., Moon, R.T., and Stainier, D.Y. (2012) Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver. Mechanisms of Development. 128(11-12):525-535
- Vemaraju, S., Kantarci, H., Padanad, M.S., and Riley, B.B. (2012) A spatial and temporal gradient of fgf differentially regulates distinct stages of neural development in the zebrafish inner ear. PLoS Genetics. 8(11):e1003068
- Wong, K.S., Proulx, K., Rost, M.S., and Sumanas, S. (2009) Identification of vasculature-specific genes by microarray analysis of etsrp/etv2 overexpressing zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(7):1836-1850
- Klee, E.W. (2008) The zebrafish secretome. Zebrafish. 5(2):131-138
- Macqueen, D.J., and Johnston, I.A. (2008) Evolution of follistatin in teleosts revealed through phylogenetic, genomic and expression analyses. Development genes and evolution. 218(1):1-14
1 - 10 of 13
Show