Gene

lats2

ID

ZDB-GENE-050119-6

Name

large tumor suppressor kinase 2

Symbol

lats2 Nomenclature History

Previous Names

si:ch211-173o4.2

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Acts upstream of with a negative effect on BMP signaling pathway. Acts upstream of or within convergent extension involved in gastrulation. Predicted to be active in nucleus and spindle pole. Is expressed in several structures, including nervous system; neural crest cell; non neural ectoderm; pectoral fin bud; and pleuroperitoneal region. Used to study peripheral nerve sheath neoplasm. Orthologous to human LATS2 (large tumor suppressor kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lats2 Human Ortholog

No data available

Associated With lats2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
peripheral nerve sheath neoplasm	lats2^mw87/mw87	standard conditions	Brandt et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR015940	Ubiquitin-associated domain
Family	IPR050236	Serine/threonine-protein kinases, AGC
Homologous_superfamily	IPR009060	UBA-like superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinases, AGC	UBA-like superfamily	Ubiquitin-associated domain
UniProtKB:B0S8I4 InterPro	1140
UniProtKB:B2BJC0 InterPro	1078
UniProtKB:B2BJC1 InterPro	1140

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lats2-201 (1) Ensembl	Ensembl	3,484 nt	Select Tool ZFIN BLAST
mRNA	lats2-202 (1) Ensembl	Ensembl	3,670 nt	Select Tool ZFIN BLAST
mRNA	lats2-203 (1) Ensembl	Ensembl	3,689 nt	Select Tool ZFIN BLAST
mRNA	lats2-204 (1) Ensembl	Ensembl	3,922 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations