Gene
flt3
- ID
- ZDB-GENE-050114-4
- Name
- fms related receptor tyrosine kinase 3
- Symbol
- flt3 Nomenclature History
- Previous Names
-
- si:ch211-140b10.8
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within macrophage differentiation and myeloid cell development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including ball; digestive system; hematopoietic system; kidney; and pericardial region. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Peng et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15012 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24498 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37884 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44134 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | Leukemia, acute lymphoblastic, somatic | 613065 |
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, reduced survival in, somatic | 601626 |
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F1P1
|
956 | ||||||||||||
|
UniProtKB:A0A8M1QKN2
|
956 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-140B10 | ||
| Contains | STS | zfishb-a511c07.q1c | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001921725 (1) | 5208 nt | ||
| Genomic | GenBank:BX571696 (2) | 171175 nt | ||
| Polypeptide | UniProtKB:A0A8M1QKN2 (1) | 956 aa |
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Silva, N.J., Dorman, L.C., Vainchtein, I.D., Horneck, N.C., Molofsky, A.V. (2021) In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Nature communications. 12:5916
- Rojo-Bartolomé, I., Santana de Souza, J.E., Diaz de Cerio, O., Cancio, I. (2020) Duplication and subfunctionalisation of the general transcription factor IIIA (gtf3a) gene in teleost genomes, with ovarian specific transcription of gtf3ab. PLoS One. 15:e0227690
- Ma, A.C., McNulty, M.S., Tanya, P.L., Jarryd, C.M., Martínez-Gálvez, G., Argue, D.P., Lee, H.B., Urban, M.D., Bullard, C.E., Blackburn, P.R., Man, T.K., Clark, K.J., Ekker, S.C. (2016) FusX: A rapid one-step TALE assembly system for genome science. Human gene therapy. 27(6):451-63
- Peng, X., Dong, M., Ma, L., Jia, X.E., Mao, J., Jin, C., Chen, Y., Gao, L., Liu, X., Ma, K., Wang, L., Du, T., Jin, Y., Huang, Q., Li, K., Zon, L.I., Liu, T., Deng, M., Zhou, Y., Xi, X., Zhou, Y., Chen, S. (2015) A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia. 29(12):2355-65
- He, B.L., Shi, X., Man, C.H., Ma, A.C., Ekker, S.C., Chow, H.C., So, C.W., Choi, W.W., Zhang, W., Zhang, Y., and Leung, A.Y. (2014) Functions of FMS-like tyrosine kinase 3 (flt3) in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia. Blood. 123(16):2518-29
- Challa, A.K., and Chatti, K. (2013) Conservation and Early Expression of Zebrafish Tyrosine Kinases Support the Utility of Zebrafish as a Model for Tyrosine Kinase Biology. Zebrafish. 10(3):264-74
- Ma, A.C., Lee, H.B., Clark, K.J., and Ekker, S.C. (2013) High Efficiency In Vivo Genome Engineering with a Simplified 15-RVD GoldyTALEN Design. PLoS One. 8(5):e65259
- Murphy, E.A., Shields, D.J., Stoletov, K., Dneprovskaia, E., McElroy, M., Greenberg, J.I., Lindquist, J., Acevedo, L.M., Anand, S., Majeti, B.K., Tsigelny, I., Saldanha, A., Walsh, B., Hoffman, R.M., Bouvet, M., Klemke, R.L., Vogt, P.K., Arnold, L., Wrasidlo, W., and Cheresh, D.A. (2010) Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFR{beta}/B-RAF. Proceedings of the National Academy of Sciences of the United States of America. 107(9):4299-4304
- Phillips, R.B., Amores, A., Morasch, M.R., Wilson, C., and Postlethwait, J.H. (2006) Assignment of zebrafish genetic linkage groups to chromosomes. Cytogenetic and genome research. 114(2):155-162
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