Gene
erbb3b
- ID
- ZDB-GENE-050107-1
- Name
- erb-b2 receptor tyrosine kinase 3b
- Symbol
- erbb3b Nomenclature History
- Previous Names
-
- hps
- hypersensitive (1)
- pcs
- picasso
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including axonal fasciculation; fin regeneration; and gliogenesis. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Is expressed in fin; heart; and nervous system. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 33 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
lethal congenital contracture syndrome 2 | Alliance | ?Lethal congenital contractural syndrome 2 | 607598 |
neuronal intestinal dysplasia type A | Alliance | Visceral neuropathy, familial, 1, autosomal recessive | 243180 |
{?Erythroleukemia, familial, susceptibility to} | 133180 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000494 | Receptor L-domain |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Domain | IPR006211 | Furin-like cysteine-rich domain |
Domain | IPR032778 | Growth factor receptor domain 4 |
Family | IPR016245 | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
Family | IPR050122 | Receptor Tyrosine Kinase |
Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
Homologous_superfamily | IPR044912 | Epidermal growth factor receptor, juxtamembrane domain |
Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
Protein | Length | Epidermal growth factor receptor, juxtamembrane domain | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q5G254
|
1429 | |||||||||||||
UniProtKB:A0A8M2B911
|
1427 | |||||||||||||
UniProtKB:A0A8M9P541
|
1426 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
erbb3b-201
(1)
|
Ensembl | 4290 nt | |
mRNA |
erbb3b-202
(1)
|
Havana | 4636 nt |
Interactions and Pathways
No data available
Plasmids
No data available