Gene
slc6a5
- ID
- ZDB-GENE-050105-2
- Name
- solute carrier family 6 member 5
- Symbol
- slc6a5 Nomenclature History
- Previous Names
-
- glyt2 (2)
- si:dkey-7n10.12
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable glycine:sodium symporter activity. Predicted to be involved in glycine import across plasma membrane; glycinergic synaptic transmission; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system and glycinergic neurons. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyperekplexia 3 | Alliance | Hyperekplexia 3 | 614618 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|
|
UniProtKB:A0A2R8Q8E9
|
778 | ||
|
UniProtKB:A0A8M3ATZ4
|
460 | ||
|
UniProtKB:Q5W8I5
|
786 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc6a5-201
(1)
|
Ensembl | 3,118 nt | ||
| mRNA |
slc6a5-202
(1)
|
Ensembl | 7,488 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-262G18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-7N10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193549 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009557 (1) | 3025 nt | ||
| Genomic | GenBank:AL954849 (1) | 162939 nt | ||
| Polypeptide | UniProtKB:Q5W8I5 (1) | 786 aa |
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Chen, Z., Long, H., Guo, J., Wang, Y., He, K., Tao, C., Li, X., Jiang, K., Guo, S., Pi, Y. (2022) Autism-Risk Gene necab2 Regulates Psychomotor and Social Behavior as a Neuronal Modulator of mGluR1 Signaling. Frontiers in molecular neuroscience. 15:901682
- Hevia, C.F., Engel-Pizcueta, C., Udina, F., Pujades, C. (2022) The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions. Cell Reports. 39:110915
- Long, F., Zheng, J., Zhou, J., Hu, P., Xiong, B. (2022) Knockout of tanc2 causes autism-like behavior and sleep disturbance in zebrafish. Autism research : official journal of the International Society for Autism Research. 16(3):524-534
- Rajan, G., Lafaye, J., Faini, G., Carbo-Tano, M., Duroure, K., Tanese, D., Panier, T., Candelier, R., Henninger, J., Britz, R., Judkewitz, B., Gebhardt, C., Emiliani, V., Debregeas, G., Wyart, C., Del Bene, F. (2022) Evolutionary divergence of locomotion in two related vertebrate species. Cell Reports. 38:110585
- de la Rocha-Muñoz, A., Núñez, E., Vishwanath, A.A., Gómez-López, S., Dhanasobhon, D., Rebola, N., López-Corcuera, B., de Juan-Sanz, J., Aragón, C. (2021) The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo. Communications biology. 4:1197
- Juárez-Morales, J.L., Weierud, F., England, S.J., Demby, C., Santos, N., Grieb, G., Mazan, S., Lewis, K.E. (2021) Evolution of lbx spinal cord expression and function. Evolution & development. 23(5):404-422
- Picton, L.D., Bertuzzi, M., Pallucchi, I., Fontanel, P., Dahlberg, E., Björnfors, E.R., Iacoviello, F., Shearing, P.R., El Manira, A. (2021) A spinal organ of proprioception for integrated motor action feedback. Neuron. 109(7):1188-1201.e7
- Wang, T., Zhou, M., Zhang, Q., Zhang, C., Peng, G. (2021) ubtor Mutation Causes Motor Hyperactivity by Activating mTOR Signaling in Zebrafish. Neuroscience Bulletin. 37(12):1658-1670
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