Gene

araf

ID
ZDB-GENE-050102-2
Name
A-Raf proto-oncogene, serine/threonine kinase
Symbol
araf Nomenclature History
Previous Names
  • sb:eu994
  • wu:fk45h07
  • zgc:92074
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits SMAD binding activity. Involved in negative regulation of nodal signaling pathway and pathway-restricted SMAD protein phosphorylation. Predicted to localize to cytosol and mitochondrion. Is expressed in head. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With araf Human Ortholog
No data available
Associated With araf Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR003116 Raf-like Ras-binding
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Family IPR050167 Serine/threonine-protein kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR046349 C1-like domain superfamily
Domain Details Per Protein
Protein Length C1-like domain superfamily Diacylglycerol/phorbol-ester binding Protein kinase, ATP binding site Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Protein kinase domain Protein kinase-like domain superfamily Raf-like Ras-binding Serine/threonine-protein kinase Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ubiquitin-like domain superfamily
UniProtKB:Q5FBD1 608
UniProtKB:Q5M7Y2 604
UniProtKB:Q75Y03 608
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA araf-201 (1) Ensembl 2,125 nt
mRNA araf-202 (1) Ensembl 2,396 nt
mRNA araf-203 (1) Ensembl 1,210 nt
mRNA araf-204 (1) Ensembl 6,809 nt
mRNA araf-205 (1) Ensembl 6,779 nt
mRNA araf-206 (1) Ensembl 1,924 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations