Gene
tfr1b
- ID
- ZDB-GENE-041220-2
- Name
- transferrin receptor 1b
- Symbol
- tfr1b Nomenclature History
- Previous Names
-
- tfrc (1)
- CD71
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have transferrin receptor activity. Involved in cellular iron ion homeostasis and hemoglobin biosynthetic process. Predicted to localize to external side of plasma membrane. Human ortholog(s) of this gene implicated in breast carcinoma; multiple myeloma; ovarian cancer; and primary immunodeficiency disease. Orthologous to human TFRC (transferrin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu958 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Wingert et al., 2004
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 46 | Alliance | Immunodeficiency 46 | 616740 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003137 | PA domain |
| Domain | IPR007484 | Peptidase M28 |
| Domain | IPR037324 | Transferrin receptor protein 1/2, PA domain |
| Family | IPR039373 | Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like |
| Homologous_superfamily | IPR036757 | Transferrin receptor-like, dimerisation domain superfamily |
| Homologous_superfamily | IPR046450 | PA domain superfamily |
Domain Details Per Protein
| Protein | Length | PA domain | PA domain superfamily | Peptidase M28 | Transferrin receptor-like, dimerisation domain superfamily | Transferrin receptor protein 1/2, PA domain | Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q32PQ5
|
771 |
Interactions and Pathways
No data available
Plasmids
No data available