Gene
arhgef7b
- ID
- ZDB-GENE-041212-49
- Name
- Rho guanine nucleotide exchange factor (GEF) 7b
- Symbol
- arhgef7b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have guanyl-nucleotide exchange factor activity. Involved in several processes, including endothelial cell proliferation; epiboly involved in gastrulation with mouth forming second; and protein localization to adherens junction. Used to study cerebrovascular disease. Is expressed in several structures, including EVL; axial vasculature; hatching gland; nervous system; and periderm. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142367 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cerebrovascular disease | arhgef7bf40a/f40a | standard conditions | Yang et al., 2017 |
| cerebrovascular disease | arhgef7bm292/m292 | standard conditions | Crilly et al., 2022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR032409 | Rho guanine nucleotide exchange factor 6/7, coiled-coil domain |
| Domain | IPR046376 | RhoGEF 6/7, PH domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
Domain Details Per Protein
| Protein | Length | Calponin homology domain | CH domain superfamily | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PH-like domain superfamily | Pleckstrin homology domain | RhoGEF 6/7, PH domain | Rho guanine nucleotide exchange factor 6/7, coiled-coil domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q952
|
842 | |||||||||||
|
UniProtKB:Q5PRA8
|
799 | |||||||||||
|
UniProtKB:F1QA07
|
643 | |||||||||||
|
UniProtKB:A0A8M6Z512
|
700 | |||||||||||
|
UniProtKB:A0A8M6Z5N5
|
856 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available