Gene

arhgef7b

ID

ZDB-GENE-041212-49

Name

Rho guanine nucleotide exchange factor (GEF) 7b

Symbol

arhgef7b Nomenclature History

Previous Names

arhgef7
bbh (1)
bpix (1)
im:7142367
wu:fc35h08
zgc:101775

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Involved in several processes, including endothelial cell proliferation; epiboly involved in gastrulation with mouth forming second; and protein localization to adherens junction. Used to study cerebrovascular disease. Is expressed in several structures, including EVL; axial vasculature; hatching gland; nervous system; and periderm. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7142367 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef7b Human Ortholog

No data available

Associated With arhgef7b Via Experimental Models

Human Disease	Fish	Conditions	Citations
cerebrovascular disease	arhgef7b^f40a/f40a	standard conditions	Yang et al., 2017
cerebrovascular disease	arhgef7b^m292/m292	standard conditions	Crilly et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001452	SH3 domain
Domain	IPR001715	Calponin homology domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR032409	Rho guanine nucleotide exchange factor 6/7, coiled-coil domain
Domain	IPR046376	RhoGEF 6/7, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Length	Calponin homology domain	CH domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PH-like domain superfamily	Pleckstrin homology domain	RhoGEF 6/7, PH domain	Rho guanine nucleotide exchange factor 6/7, coiled-coil domain	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M9Q952 InterPro	842
UniProtKB:Q5PRA8 InterPro	799
UniProtKB:F1QA07 InterPro	643
UniProtKB:A0A8M6Z512 InterPro	700
UniProtKB:A0A8M6Z5N5 InterPro	856

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	arhgef7b-201 (1) Ensembl	Ensembl		3,341 nt	Select Tool ZFIN BLAST
mRNA	arhgef7b-202 (1) Ensembl	Ensembl		3,570 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations