Gene
sim1b
- ID
- ZDB-GENE-041210-5
- Name
- SIM bHLH transcription factor 1b
- Symbol
- sim1b Nomenclature History
- Previous Names
-
- Sim1 (1)
- si:ch211-152c2.1
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation; nervous system development; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Is expressed in caudal tuberculum; diencephalon; hypothalamus; midbrain; and preoptic area. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Löhr et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR010578 | Single-minded, C-terminal |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013655 | PAS fold-3 |
| Domain | IPR013767 | PAS fold |
| Family | IPR001067 | Nuclear translocator |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold | PAS fold-3 | Single-minded, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:C1JIE2
|
586 | |||||||||
|
UniProtKB:A0A8M9PUK5
|
578 | |||||||||
|
UniProtKB:A0A8M9PHD1
|
585 | |||||||||
|
UniProtKB:A0A8M9Q0L7
|
577 |
Interactions and Pathways
No data available
Plasmids
No data available