Gene

pde3a

ID

ZDB-GENE-041210-23

Name

phosphodiesterase 3A, cGMP-inhibited

Symbol

pde3a Nomenclature History

Previous Names

si:dkey-48h7.2

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in several processes, including cyclic-nucleotide-mediated signaling; negative regulation of cAMP-mediated signaling; and oocyte maturation. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Is expressed in oocyte and oocyte stage V. Orthologous to human PDE3A (phosphodiesterase 3A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Pang et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pde3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypertension and brachydactyly syndrome	Alliance	Hypertension and brachydactyly syndrome	112410

Associated With pde3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain	IPR003607	HD/PDEase domain
Homologous_superfamily	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily	3'5'-cyclic nucleotide phosphodiesterase, conserved site	HD/PDEase domain
UniProtKB:F6P4K3 InterPro	1117
UniProtKB:A0A8M3ARD3 InterPro	1123
UniProtKB:A0A8M3B8Q1 InterPro	1124
UniProtKB:A0A8M3AYI3 InterPro	1106

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pde3a-201 (1) Ensembl	Ensembl		4,005 nt	Select Tool
mRNA	pde3a-202 (1) Ensembl	Ensembl		3,150 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations