Gene
grb2a
- ID
- ZDB-GENE-041121-1
- Name
- growth factor receptor-bound protein 2a
- Symbol
- grb2a Nomenclature History
- Previous Names
-
- zgc:103549
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have SH3/SH2 adaptor activity. Predicted to localize to nucleoplasm. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Mauri et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR035641 | GRB2, N-terminal SH3 domain |
| Domain | IPR035643 | GRB2, C-terminal SH3 domain |
| Family | IPR043539 | Grb2-like |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | GRB2, C-terminal SH3 domain | Grb2-like | GRB2, N-terminal SH3 domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5RKN6
|
217 |
Interactions and Pathways
No data available
Plasmids
No data available