Gene
cdca8
- ID
- ZDB-GENE-041114-171
- Name
- cell division cycle associated 8
- Symbol
- cdca8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within heart development. Predicted to be located in several cellular components, including chromosome; cytoskeleton; and nucleus. Predicted to be part of chromosome passenger complex. Predicted to be active in chromosome, centromeric region and spindle midzone. Is expressed in proliferative region. Orthologous to human CDCA8 (cell division cycle associated 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb373 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Phenotype Annotation (1994-2006)
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hi1780aTg | Transgenic insertion | Intron 2 | Unknown | DNA | |
hi2039bTg | Transgenic insertion | Intron 2 | Unknown | DNA | |
la020901Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028075Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa43350 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa43351 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Borealin, C-terminal | Borealin, N-terminal | Cell division protein borealin |
---|---|---|---|---|
UniProtKB:Q5XLR4
|
276 | |||
UniProtKB:B2GQ71
|
276 | |||
UniProtKB:F1RBV2
|
276 | |||
UniProtKB:A0A8M6YUH5
|
275 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-15N15 | ZFIN Curated Data | |
Encodes | EST | cb373 | Thisse et al., 2001 | |
Encodes | cDNA | MGC:101607 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191801 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001007456 (1) | 1885 nt | ||
Genomic | GenBank:FP102191 (1) | 82601 nt | ||
Polypeptide | UniProtKB:B2GQ71 (1) | 276 aa |
- Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
- Tambalo, M., Mitter, R., Wilkinson, D.G. (2020) A single cell transcriptome atlas of the developing zebrafish hindbrain. Development (Cambridge, England). 147(6):
- Hsu, A.Y., Wang, D., Liu, S., Lu, J., Syahirah, R., Bennin, D.A., Huttenlocher, A., Umulis, D.M., Wan, J., Deng, Q. (2019) Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. Proceedings of the National Academy of Sciences of the United States of America. 116(37):18561-18570
- Zhang, X., Li, X., Li, R., Zhang, Y., Li, Y., Li, S. (2019) Transcriptomic profile of early zebrafish PGCs by single cell sequencing. PLoS One. 14:e0220364
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Sampath, S.C., Ohi, R., Leismann, O., Salic, A., Pozniakovski, A., and Funabiki, H. (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell. 118(2):187-202
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