Gene
cadm4
- ID
- ZDB-GENE-041114-138
- Name
- cell adhesion molecule 4
- Symbol
- cadm4 Nomenclature History
- Previous Names
-
- zgc:101704 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable vascular endothelial growth factor receptor 2 binding activity. Acts upstream of or within bulbus arteriosus formation; glial cell development; and retina development in camera-type eye. Predicted to be located in membrane. Predicted to be active in cell-cell contact zone. Is expressed in basal plate midbrain region; immature eye; nervous system; and presumptive bulbus arteriosus. Orthologous to human CADM4 (cell adhesion molecule 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101704 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cu24 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la019650Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12426 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36121 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CD80-like, immunoglobulin C2-set | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Neurexin/syndecan/glycophorin C |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B4F3
|
415 | ||||||||
|
UniProtKB:A0A8M2B4X9
|
393 | ||||||||
|
UniProtKB:B0CLV3
|
413 | ||||||||
|
UniProtKB:Q5U3R8
|
389 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-79K12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-88N1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-213B7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-98D7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101704 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191886 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007428 (1) | 2760 nt | ||
| Genomic | GenBank:CR854851 (2) | 218036 nt | ||
| Polypeptide | UniProtKB:A0A8M2B4F3 (1) | 415 aa |
- Wang, D., Wang, X., Huang, H., Wang, H. (2021) Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Journal of hazardous materials. 413:125414
- Baek, S., Oh, T.G., Secker, G., Sutton, D.L., Okuda, K.S., Paterson, S., Bower, N.I., Toubia, J., Koltowska, K., Capon, S.J., Baillie, G.J., Simons, C., Muscat, G.E.O., Lagendijk, A.K., Smith, K.A., Harvey, N.L., Hogan, B.M. (2019) The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Developmental Cell. 49:279-292.e5
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gao, X., Metzger, U., Panza, P., Mahalwar, P., Alsheimer, S., Geiger, H., Maischein, H.M., Levesque, M.P., Templin, M., Söllner, C. (2015) A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Cell Reports. 12(4):694-708
- Zeng, X.X., Yelon, D. (2014) Cadm4 Restricts the Production of Cardiac Outflow Tract Progenitor Cells. Cell Reports. 7(4):951-60
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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