Gene

myo5aa

ID

ZDB-GENE-041027-2

Name

myosin VAa

Symbol

myo5aa Nomenclature History

Previous Names

myo5a
si:dkey-266j9.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and vesicle. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo5aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Griscelli syndrome type 1	Alliance	Griscelli syndrome, type 1	214450

Associated With myo5aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR002710	Dilute domain
Domain	IPR004009	Myosin, N-terminal, SH3-like
Domain	IPR036103	Class V myosin, motor domain
Domain	IPR037988	Myosin 5a, cargo-binding domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Class V myosin, motor domain	Dilute domain	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Myosin 5a, cargo-binding domain	Myosin, N-terminal, SH3-like	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M3AJS5 InterPro	1846
UniProtKB:A0A8M2BKY7 InterPro	1828
UniProtKB:A0A8M9PPP8 InterPro	1850
UniProtKB:A0A8M3B332 InterPro	1825
UniProtKB:A0A8M9PW04 InterPro	1849
UniProtKB:A0A8M2BKY1 InterPro	1827
UniProtKB:A0A8M9P1G5 InterPro	1368
UniProtKB:A0A8M9PAJ4 InterPro	1340
UniProtKB:A0A8M9PPQ8 InterPro	1854
UniProtKB:A0A8M3AV30 InterPro	1848
UniProtKB:A0A8M3AS48 InterPro	1847

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myo5aa-201 (1) Ensembl	Ensembl	5,535 nt	Select Tool ZFIN BLAST
mRNA	myo5aa-202 (1) Ensembl	Ensembl	5,535 nt	Select Tool ZFIN BLAST
mRNA	myo5aa-203 (1) Ensembl	Ensembl	844 nt	Select Tool ZFIN BLAST
mRNA	myo5aa-204 (1) Ensembl	Ensembl	5,735 nt	Select Tool ZFIN BLAST
mRNA	myo5aa-206 (1) Ensembl	Ensembl	5,809 nt	Select Tool ZFIN BLAST
ncRNA	myo5aa-005 (1) Ensembl	Ensembl	815 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations