Gene

tll1

ID

ZDB-GENE-041020-1

Name

tolloid-like 1

Symbol

tll1 Nomenclature History

Previous Names

tld (1)
mfn
mini fin
tolloid (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Exhibits metallopeptidase activity. Involved in several processes, including determination of ventral identity; embryonic morphogenesis; and post-anal tail morphogenesis. Human ortholog(s) of this gene implicated in atrial heart septal defect 6. Is expressed in margin; neural plate; tail bud; vascular cord; and vasculature. Orthologous to human TLL1 (tolloid like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 23 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tll1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
atrial heart septal defect 6	Alliance	Atrial septal defect 6	613087

Associated With tll1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000859	CUB domain
Domain	IPR001506	Peptidase M12A
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR006026	Peptidase, metallopeptidase
Domain	IPR034036	Tolloid/BMP1 peptidase domain
Family	IPR015446	Bone morphogenetic protein 1/tolloid-like protein
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR035914	Spermadhesin, CUB domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site