Gene
klf7b
- ID
- ZDB-GENE-041014-171
- Name
- Kruppel like factor 7b
- Symbol
- klf7b Nomenclature History
- Previous Names
-
- klf7l
- si:dkey-101c24.1
- zgc:153366
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within optic nerve formation. Predicted to be located in membrane. Is expressed in nervous system; neural rod; and trigeminal placode. Orthologous to human KLF7 (KLF transcription factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6905816 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026875Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8567 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31720 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31721 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:Q5TYN4
|
295 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-90K7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-101C24 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6905816 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:153366 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173491 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192466 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044766 (1) | 2625 nt | ||
| Genomic | GenBank:CR381621 (2) | 196065 nt | ||
| Polypeptide | UniProtKB:Q5TYN4 (1) | 295 aa |
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Shao, M., Ge, G.Z., Liu, W.J., Xiao, J., Xia, H.J., Fan, Y., Zhao, F., He, B.L., Chen, C. (2017) Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Oncotarget. 8(10):16325-16339
- Bhattarai, S., Sochacka-Marlowe, A., Crutchfield, G., Khan, R., Londraville, R., Liu, Q. (2016) Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous system. Gene expression patterns : GEP. 21(1):41-53
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xue, Y., Gao, S., Liu, F. (2015) Genome-wide Analysis of the Zebrafish Klf Family Identifies Two Genes important for Erythroid Maturation. Developmental Biology. 403(2):115-27
- Elsaeidi, F., Bemben, M.A., Zhao, X.F., and Goldman, D. (2014) Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(7):2632-2644
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Veldman, M.B., Bemben, M.A., and Goldman, D. (2010) Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Molecular and cellular neurosciences. 43(4):370-383
- Veldman, M.B., Bemben, M.A., Thompson, R.C., and Goldman, D. (2007) Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Developmental Biology. 312(2):596-612
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 10 of 11
Show