Gene
met
- ID
- ZDB-GENE-041014-1
- Name
- MET proto-oncogene, receptor tyrosine kinase
- Symbol
- met Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have hepatocyte growth factor-activated receptor activity. Involved in generation of neurons; gland development; and pectoral fin development. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Is expressed in several structures, including anterior neural rod; endocrine system; gut; musculature system; and nervous system. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153684 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal recessive nonsyndromic deafness 97 | Alliance | ?Deafness, autosomal recessive 97 | 616705 |
hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, childhood type, somatic | 114550 |
papillary renal cell carcinoma | Alliance | Renal cell carcinoma, papillary, 1, familial and somatic | 605074 |
?Arthrogryposis, distal, type 11 | 620019 | ||
{Osteofibrous dysplasia, susceptibility to} | 607278 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008266 | Tyrosine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Domain | IPR001627 | Sema domain |
Domain | IPR002909 | IPT domain |
Domain | IPR016201 | PSI domain |
Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
Family | IPR016244 | Tyrosine-protein kinase, HGF/MSP receptor |
Family | IPR031148 | Plexin family |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Homologous_superfamily | IPR036352 | Sema domain superfamily |
Repeat | IPR002165 | Plexin repeat |
Domain Details Per Protein
Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin family | Plexin repeat | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | PSI domain | Sema domain | Sema domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, HGF/MSP receptor | WD40/YVTN repeat-like-containing domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q64GK4
|
1382 | ||||||||||||||||
UniProtKB:F1QLR7
|
1382 | ||||||||||||||||
UniProtKB:A0A8M2BA12
|
1335 |
Interactions and Pathways
Plasmids
No data available