Gene

ppp1r12a

ID

ZDB-GENE-041011-3

Name

protein phosphatase 1, regulatory subunit 12A

Symbol

ppp1r12a Nomenclature History

Previous Names

mypt1 (1)
myosin phosphatase targeting subunit 1 (1)
myosin-binding subunit of myosin phosphatase (1)
si:dkey-28j4.1 (1)
unm p82emcf
unm_p82emcf
zgc:110448 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Exhibits protein heterodimerization activity. Involved in several processes, including actin filament bundle organization; convergent extension involved in axis elongation; and nervous system development. Predicted to localize to A band; PTW/PP1 phosphatase complex; and Z disc. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and myotome. Orthologous to several human genes including PPP1R12A (protein phosphatase 1 regulatory subunit 12A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 36 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppp1r12a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Genitourinary and/or/brain malformation syndrome	618820

Associated With ppp1r12a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR031775	cGMP-dependent protein kinase, interacting domain
Family	IPR017401	Protein phosphatase 1 regulatory subunit 12A/B/C
Family	IPR051226	Protein Phosphatase 1 Regulatory Subunit
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	cGMP-dependent protein kinase, interacting domain	Protein Phosphatase 1 Regulatory Subunit	Protein phosphatase 1 regulatory subunit 12A/B/C
UniProtKB:A0A8M9PH66 InterPro	1065
UniProtKB:Q6DRG7 InterPro	1049
UniProtKB:A0A8M6YX05 InterPro	1081
UniProtKB:A0A8M9QB53 InterPro	1097
UniProtKB:A0A8M9PUD2 InterPro	1049
UniProtKB:A0A8M9Q0E6 InterPro	1001
UniProtKB:A0A8M9Q5V2 InterPro	1090

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ppp1r12a-201 (1) Ensembl	Ensembl	4,846 nt	Select Tool ZFIN BLAST
mRNA	ppp1r12a-tv201 (1)		3,313 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ppp1r12a-tv202 (1)		3,032 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations