Gene

rad51c

ID

ZDB-GENE-041010-204

Name

RAD51 paralog C

Symbol

rad51c Nomenclature History

Previous Names

fanco (1)
zgc:101596 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity; ATP-dependent activity, acting on DNA; and DNA binding activity. Predicted to contribute to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Predicted to be involved in meiotic DNA recombinase assembly and reciprocal meiotic recombination. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex and Rad51C-XRCC3 complex. Predicted to be active in replication fork. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101596 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rad51c Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fanconi anemia complementation group O	Alliance	Fanconi anemia, complementation group O	613390
		{Breast-ovarian cancer, familial, susceptibility to, 3}	613399

Associated With rad51c Via Experimental Models

Human Disease	Fish	Conditions	Citations
Fanconi anemia	rad51c^hg65/hg65 (NHGRI-1)	standard conditions	Raman et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR013632	DNA recombination and repair protein Rad51-like, C-terminal
Domain	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain
Family	IPR016467	DNA recombination and repair protein, RecA-like
Family	IPR052093	Homologous Recombination Repair Mediator
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase