mhc2dhb

ID

ZDB-GENE-041010-13

Name

major histocompatibility complex class II DHB gene

Symbol

mhc2dhb Nomenclature History

Previous Names

• MHCII (1)
• zgc:103700

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable MHC class II protein complex binding activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Is expressed in yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including HLA-DOB (major histocompatibility complex, class II, DO beta); HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); and HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1).

Genome Resources

• Alliance (1)
• Gene:103911540 (1)
• Ensembl(GRCz11):ENSDARG00000116524 (1)

Note

None

Comparative Information