Gene
usp4
- ID
- ZDB-GENE-041008-187
- Name
- ubiquitin specific peptidase 4 (proto-oncogene)
- Symbol
- usp4 Nomenclature History
- Previous Names
-
- im:7139722
- unpEL (1)
- wu:fa11d11
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have thiol-dependent ubiquitin-specific protease activity. Involved in convergent extension; negative regulation of toll-like receptor signaling pathway; and protein deubiquitination. Predicted to localize to nucleus. Orthologous to human USP4 (ubiquitin specific peptidase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139722 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR006615 | Peptidase C19, ubiquitin-specific peptidase, DUSP domain |
| Domain | IPR028135 | Ubiquitin-like domain, USP-type |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Domain | IPR029346 | Ubiquitin carboxyl-terminal hydrolase, C-terminal |
| Family | IPR050185 | Ubiquitin carboxyl-terminal hydrolase |
| Homologous_superfamily | IPR035927 | DUSP-like superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | DUSP-like superfamily | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Peptidase C19, ubiquitin-specific peptidase, DUSP domain | Ubiquitin carboxyl-terminal hydrolase | Ubiquitin carboxyl-terminal hydrolase, C-terminal | Ubiquitin-like domain, USP-type | Ubiquitin specific protease, conserved site | Ubiquitin specific protease domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7EZD6
|
1009 |
Interactions and Pathways
No data available
Plasmids
No data available