Gene

usp28

ID

ZDB-GENE-041008-142

Name

ubiquitin specific peptidase 28

Symbol

usp28 Nomenclature History

Previous Names

im:7138195

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. Involved in central nervous system morphogenesis. Orthologous to human USP28 (ubiquitin specific peptidase 28).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7138195 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Tse et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usp28 Human Ortholog

No data available

Associated With usp28 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018200	Ubiquitin specific protease, conserved site
Conserved_site	IPR054108	Ubiquitin carboxyl-terminal hydrolase 25/28, UIM
Domain	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain	IPR028889	Ubiquitin specific protease domain
Domain	IPR054109	UBA-like domain
Family	IPR044635	Ubiquitin carboxyl-terminal hydrolase 14-like
Homologous_superfamily	IPR009060	UBA-like superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	Papain-like cysteine peptidase superfamily	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	UBA-like domain	UBA-like superfamily	Ubiquitin carboxyl-terminal hydrolase 14-like	Ubiquitin carboxyl-terminal hydrolase 25/28, UIM	Ubiquitin specific protease, conserved site	Ubiquitin specific protease domain
UniProtKB:A0A8M9PR33 InterPro	1159
UniProtKB:A0A8M1QHC1 InterPro	1163
UniProtKB:A0A8M9P3R8 InterPro	1138

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	usp28-201 (1) Ensembl	Ensembl	4,785 nt	Select Tool ZFIN BLAST
mRNA	usp28-202 (1) Ensembl	Ensembl	3,653 nt	Select Tool
mRNA	usp28-203 (1) Ensembl	Ensembl	4,821 nt	Select Tool ZFIN BLAST
mRNA	usp28-204 (1) Ensembl	Ensembl	4,893 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations