Gene
ryr3
- ID
- ZDB-GENE-041001-165
- Name
- ryanodine receptor 3
- Symbol
- ryr3 Nomenclature History
- Previous Names
-
- ryrg (1)
- si:ch211-189g6.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable calcium-induced calcium release activity and ryanodine-sensitive calcium-release channel activity. Involved in nervous system development; skeletal muscle fiber development; and smoothened signaling pathway. Predicted to be located in membrane and sarcoplasmic reticulum. Predicted to be part of calcium channel complex. Predicted to be active in Z disc; endoplasmic reticulum; and sarcolemma. Is expressed in Kupffer's vesicle; brain; musculature system; neurons; and somite. Orthologous to human RYR3 (ryanodine receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1589 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013845Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021515Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa956 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa7471 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa9285 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9447 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| z45 | Allele with one deletion | Exon 6 | Frameshift, Premature Stop | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myopathy 20 | Alliance | Congenital myopathy 20 | 620310 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EF-hand domain | EF-hand domain pair | Inositol 1,4,5-trisphosphate/ryanodine receptor | Ion transport domain | Mir domain superfamily | MIR motif | RIH domain | Ryanodine/Inositol 1,4,5-trisphosphate receptor | Ryanodine receptor | Ryanodine receptor, junctional solenoid domain | Ryanodine receptor Ryr | Ryanodine receptor, SPRY domain 1 | Ryanodine receptor, SPRY domain 2 | Ryanodine receptor, SPRY domain 3 | Ryanodine Receptor TM 4-6 | RyR/IP3 receptor binding core, RIH domain superfamily | RyR/IP3R Homology associated domain | SPRY domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ATC3
|
4856 | |||||||||||||||||||||
|
UniProtKB:A0A8M3AWD0
|
4857 | |||||||||||||||||||||
|
UniProtKB:A0A8M3ALN1
|
4863 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-38E16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-189G6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-81B15 | ZFIN Curated Data | |
| Encodes | EST | eu1589 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009294773 (1) | 15822 nt | ||
| Genomic | GenBank:BX248136 (1) | 222316 nt | ||
| Polypeptide | UniProtKB:A0A8M3ALN1 (1) | 4863 aa |
- Bai, C., Zheng, Y., Tian, L., Lin, J., Song, Y., Huang, C., Dong, Q., Chen, J. (2023) Structure-based developmental toxicity and ASD-phenotypes of bisphenol A analogues in embryonic zebrafish. Ecotoxicology and environmental safety. 253:114643114643
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Gupta, R.K., Wasilewska, I., Palchevska, O., Kuźnicki, J. (2020) Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. International Journal of Molecular Sciences. 21(17):
- Shen, C., Zhou, Y., Tang, C., He, C., Zuo, Z. (2020) Developmental exposure to mepanipyrim induces locomotor hyperactivity in zebrafish (Danio rerio) larvae. Chemosphere. 256:127106
- Chagovetz, A.A., Klatt Shaw, D., Ritchie, E., Hoshijima, K., Grunwald, D.J. (2019) Interactions among Ryanodine Receptor isotypes contribute to muscle fiber type development and function. Disease models & mechanisms. 13(2):
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Ma, Z., Liu, H., Yu, H. (2019) Triclosan affects Ca2+ regulatory module and musculature development in skeletal myocyte during early life stage of zebrafish (Danio rerio). Environmental science & technology. 53(20):11988-11998
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Frank, D.F., Miller, G.W., Harvey, D.J., Brander, S.M., Geist, J., Connon, R.E., Lein, P.J. (2018) Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 200:50-61
- Klatt Shaw, D., Gunther, D., Jurynec, M.J., Chagovetz, A.A., Ritchie, E., Grunwald, D.J. (2018) Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling. Developmental Cell. 45(4):512-525.e5
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