Gene

map3k7

ID

ZDB-GENE-041001-135

Name

mitogen-activated protein kinase kinase kinase 7

Symbol

map3k7 Nomenclature History

Previous Names

si:ch211-225h9.1 (1)
tak1 (1)
zgc:110612 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have MAP kinase kinase kinase activity. Involved in blood vessel morphogenesis. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110612 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map3k7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
frontometaphyseal dysplasia 2	Alliance	Frontometaphyseal dysplasia 2	617137
		Cardiospondylocarpofacial syndrome	157800

Associated With map3k7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Family	IPR049637	Mitogen-activated protein kinase kinase kinase 7
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase kinase kinase 7	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:A0A8M3AT57 InterPro	578
UniProtKB:Q503G7 InterPro	544

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	map3k7-205 (1) Ensembl	Ensembl	871 nt	Select Tool
mRNA	map3k7-201 (1) Ensembl	Ensembl	4,042 nt	Select Tool
mRNA	map3k7-202 (1) Ensembl	Ensembl	870 nt	Select Tool
mRNA	map3k7-203 (1) Ensembl	Ensembl	820 nt	Select Tool
mRNA	map3k7-207 (1) Ensembl	Ensembl	4,689 nt	Select Tool ZFIN BLAST
ncRNA	map3k7-004 (1) Ensembl	Ensembl	909 nt	Select Tool
ncRNA	map3k7-006 (1) Ensembl	Ensembl	915 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations