Gene
mthfd1l
- ID
- ZDB-GENE-041001-133
- Name
- methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
- Symbol
- mthfd1l Nomenclature History
- Previous Names
-
- fk48e08
- si:dkey-25e12.5
- si:dkey-25e12.6
- wu:fk48e08
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable methenyltetrahydrofolate cyclohydrolase activity and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in cytosol. Is expressed in anterior neural tube and optic cup. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Hsiao et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020628 | Formate-tetrahydrofolate ligase, FTHFS, conserved site |
| Domain | IPR020630 | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain |
| Domain | IPR020631 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain |
| Family | IPR000559 | Formate-tetrahydrofolate ligase, FTHFS |
| Family | IPR000672 | Tetrahydrofolate dehydrogenase/cyclohydrolase |
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Domain Details Per Protein
| Protein | Length | Aminoacid dehydrogenase-like, N-terminal domain superfamily | Formate-tetrahydrofolate ligase, FTHFS | Formate-tetrahydrofolate ligase, FTHFS, conserved site | NAD(P)-binding domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Tetrahydrofolate dehydrogenase/cyclohydrolase | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QQ79
|
978 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mthfd1l-201
(1)
|
Ensembl | 5,521 nt | ||
| mRNA |
mthfd1l-202
(1)
|
Ensembl | 854 nt | ||
| mRNA |
mthfd1l-205
(1)
|
Ensembl | 464 nt | ||
| mRNA |
mthfd1l-206
(1)
|
Ensembl | 5,750 nt | ||
| ncRNA |
mthfd1l-003
(1)
|
Ensembl | 541 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-25E12 | ZFIN Curated Data | |
| Encodes | EST | fk48e08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001242996 (1) | 5750 nt | ||
| Genomic | GenBank:BX537272 (1) | 210184 nt | ||
| Polypeptide | UniProtKB:F1QQ79 (1) | 978 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Hsiao, T.H., Lee, G.H., Chang, Y.S., Chen, B.H., Fu, T.F. (2021) The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects. Frontiers in cell and developmental biology. 9:702969
- Zhang, X.Y., Liu, Y.H., Liu, D.Z., Xu, J.Y., Zhang, Q. (2021) Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics. Pharmaceuticals (Basel, Switzerland). 14(7):
- Lee, Y., Park, J., Kim, S.M., Nam, K., Lee, W., Cho, H., Han, I.O. (2020) Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:853-864
- Lee, M.S., Bonner, J.R., Bernard, D.J., Sanchez, E.L., Sause, E.T., Prentice, R.R., Burgess, S.M., and Brody, L.C. (2012) Disruption of the folate pathway in zebrafish causes developmental defects. BMC Developmental Biology. 12(1):12
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