Gene

kdr

ID

ZDB-GENE-041001-112

Name

kinase insert domain receptor (a type III receptor tyrosine kinase)

Symbol

kdr Nomenclature History

Previous Names

kdrb
si:busm1-205d10.1
si:ch211-254j6.1
si:ch211-278f21.4
vegfr2b (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in angiogenesis. Predicted to localize to endoplasmic reticulum; integral component of plasma membrane; and receptor complex. Is expressed in several structures, including axis; endocardium; intermediate cell mass of mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in artery disease (multiple); macular degeneration (multiple); pancreatic cancer; and urinary bladder cancer. Orthologous to human KDR (kinase insert domain receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

22 figures from 19 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kdr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hemangioma, capillary infantile, somatic	602089
		{Hemangioma, capillary infantile, susceptibility to}	602089

Associated With kdr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR041348	VEGFR-2, transmembrane domain
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily