Gene
kdr
- ID
- ZDB-GENE-041001-112
- Name
- kinase insert domain receptor (a type III receptor tyrosine kinase)
- Symbol
- kdr Nomenclature History
- Previous Names
-
- kdrb
- si:busm1-205d10.1
- si:ch211-254j6.1
- si:ch211-278f21.4
- vegfr2b (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable vascular endothelial growth factor receptor activity. Acts upstream of or within angiogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including axis; endocardium; intermediate cell mass of mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns32 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| mn0383Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13239 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23684 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43425 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43426 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uq38bh | Allele with one insertion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site | VEGFR-2, transmembrane domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5GIT4
|
1357 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kdr-201
(1)
|
Ensembl | 5,381 nt | ||
| mRNA | ottdart00000005209 (1) | Havana | 1,393 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(kdr:EGFP) |
|
| 1 | (5) | |
| Tg2(kdr:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-254J6 | ||
| Contained in | BAC | CH211-278F21 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-205D10 | ||
| Encodes | cDNA | MGC:195121 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001024653 (1) | 5360 nt | ||
| Genomic | GenBank:BX088688 (1) | 179801 nt | ||
| Polypeptide | UniProtKB:Q5GIT4 (1) | 1357 aa |
- Ng, M.F., Da Silva Viana, J., Tan, P.J., Britto, D.D., Choi, S.B., Kobayashi, S., Samat, N., Song, D.S.S., Ogawa, S., Parhar, I.S., Astin, J.W., Hogan, B.M., Patel, V., Okuda, K.S. (2024) Canthin-6-One Inhibits Developmental and Tumour-Associated Angiogenesis in Zebrafish. Pharmaceuticals (Basel, Switzerland). 17(1):
- Nys, N., Khatib, A.M., Siegfried, G. (2024) Apela promotes blood vessel regeneration and remodeling in zebrafish. Scientific Reports. 14:37183718
- Chen, J., Baxi, K., Lipsitt, A.E., Hensch, N.R., Wang, L., Sreenivas, P., Modi, P., Zhao, X.R., Baudin, A., Robledo, D.G., Bandyopadhyay, A., Sugalski, A., Challa, A.K., Kurmashev, D., Gilbert, A.R., Tomlinson, G.E., Houghton, P., Chen, Y., Hayes, M.N., Chen, E.Y., Libich, D.S., Ignatius, M.S. (2023) Defining function of wild-type and three patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma. eLIFE. 12:
- Da'as, S.I., Ahmed, I., Hasan, W.H., Abdelrahman, D.A., Aliyev, E., Nisar, S., Bhat, A.A., Joglekar, M.V., Hardikar, A.A., Fakhro, K.A., Akil, A.S.A. (2023) The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature. Journal of translational medicine. 21:171171
- Deshmukh, D., Hsu, Y.F., Chiu, C.C., Jadhao, M., Hsu, S.C.N., Hu, S.Y., Yang, S.H., Liu, W. (2023) Antiangiogenic potential of Lepista nuda extract suppressing MAPK/p38 signaling-mediated developmental angiogenesis in zebrafish and HUVECs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 159:114219114219
- He, Y., Kam, H., Wu, X., Chen, Q., Lee, S.M.Y. (2023) Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption. Chinese Medicine. 18:108108
- Zhou, L., Zhang, W., Xiang, Y., Qian, Z., Zhou, J., Ni, L., Feng, Y., Gao, B. (2023) The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC. Open life sciences. 18:2022053320220533
- Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
- Wang, X., Guo, H., Yu, F., Zhang, H., Peng, Y., Wang, C., Wei, G., Yan, J. (2022) Keratin5-cytoskeleton-BMP4 network regulates cell phenotype conversions during cardiac regeneration. Experimental cell research. 418(1):113272
- Wohlfart, D.P., Lou, B., Middel, C.S., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Hell, R., Hammes, H.P., Szendrödi, J., Nawroth, P.P., Kroll, J. (2022) Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biology. 50:102249
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