Gene
ass1
- ID
- ZDB-GENE-040912-178
- Name
- argininosuccinate synthase 1
- Symbol
- ass1 Nomenclature History
- Previous Names
-
- ass (1)
- wu:fb95a04
- wu:fc01e08
- zgc:92051
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have argininosuccinate synthase activity. Predicted to be involved in arginine biosynthetic process; argininosuccinate metabolic process; and urea cycle. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Is expressed in several structures, including DEL; ball; endoderm; forerunner cell group; and liver. Orthologous to human ASS1 (argininosuccinate synthase 1).
- Genome Resources
-
- Alliance (1)
- Gene:447864 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92051 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| classic citrullinemia | Alliance | Citrullinemia | 215700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018223 | Argininosuccinate synthase, conserved site |
| Domain | IPR048267 | Arginosuccinate synthase-like, N-terminal domain |
| Domain | IPR048268 | Arginosuccinate synthase C-terminal domain |
| Family | IPR001518 | Argininosuccinate synthase |
| Family | IPR023434 | Argininosuccinate synthase, type 1 subfamily |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR024074 | Argininosuccinate synthetase, catalytic/multimerisation domain body |
Domain Details Per Protein
| Protein | Length | Argininosuccinate synthase | Argininosuccinate synthase, conserved site | Argininosuccinate synthase, type 1 subfamily | Argininosuccinate synthetase, catalytic/multimerisation domain body | Arginosuccinate synthase C-terminal domain | Arginosuccinate synthase-like, N-terminal domain | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I24
|
414 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance