Gene
ass1
- ID
- ZDB-GENE-040912-178
- Name
- argininosuccinate synthase 1
- Symbol
- ass1 Nomenclature History
- Previous Names
-
- ass (1)
- wu:fb95a04
- wu:fc01e08
- zgc:92051
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable argininosuccinate synthase activity. Predicted to be involved in arginine biosynthetic process; argininosuccinate metabolic process; and urea cycle. Predicted to act upstream of or within amino acid biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including DEL; ball; brain; endoderm; and forerunner cell group. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1).
- Genome Resources
-
- Alliance (1)
- Gene:447864 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92051 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| classic citrullinemia | Alliance | Citrullinemia | 215700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018223 | Argininosuccinate synthase, conserved site |
| Domain | IPR048267 | Arginosuccinate synthase-like, N-terminal domain |
| Domain | IPR048268 | Arginosuccinate synthase C-terminal domain |
| Family | IPR001518 | Argininosuccinate synthase |
| Family | IPR023434 | Argininosuccinate synthase, type 1 subfamily |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR024074 | Argininosuccinate synthetase, catalytic/multimerisation domain body |
Domain Details Per Protein
| Protein | Length | Argininosuccinate synthase | Argininosuccinate synthase, conserved site | Argininosuccinate synthase, type 1 subfamily | Argininosuccinate synthetase, catalytic/multimerisation domain body | Arginosuccinate synthase C-terminal domain | Arginosuccinate synthase-like, N-terminal domain | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I24
|
414 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance