Gene
fabp4a
- ID
- ZDB-GENE-040912-132
- Name
- fatty acid binding protein 4a
- Symbol
- fabp4a Nomenclature History
- Previous Names
-
- fabp11
- fabp11a
- fabp4 (1)
- zgc:103587
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid binding activity. Acts upstream of or within eye development. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; immature eye; muscle; nervous system; and pleuroperitoneal region. Orthologous to several human genes including FABP4 (fatty acid binding protein 4) and FABP5 (fatty acid binding protein 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103587 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calycin | Cytosolic fatty-acid binding | Intracellular lipid binding protein | Lipocalin/cytosolic fatty-acid binding domain |
|---|---|---|---|---|---|
|
UniProtKB:Q66I80
|
134 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fabp4a-201
(1)
|
Ensembl | 674 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-241P5 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-423L13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103587 | ZFIN Curated Data | |
| interacts with | Promoter | fabp4a_promoter | Laprairie et al., 2017 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004682 (1) | 687 nt | ||
| Genomic | GenBank:CT027607 (2) | 135547 nt | ||
| Polypeptide | UniProtKB:Q66I80 (1) | 134 aa |
- Tian, Y., Lautrup, S., Law, P.W.N., Dinh, N.D., Fang, E.F., Chan, W.Y. (2024) WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome. Cell & Bioscience. 14:77
- Wang, X., Li, X., Wang, Y., Ren, Z., Du, X., Gao, J., Ji, G., Liu, Z. (2024) Nkx1.2 deletion decreases fat production in zebrafish. Obesity (Silver Spring, Md.). 32(7):1315-1328
- Grepper, D., Tabasso, C., Aguettaz, A., Martinotti, A., Ebrahimi, A., Lagarrigue, S., Amati, F. (2023) Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids. Molecular metabolism. 68:101669
- Grimm, L., Mason, E., Yu, H., Dudczig, S., Panara, V., Chen, T., Bower, N.I., Paterson, S., Rondon Galeano, M., Kobayashi, S., Senabouth, A., Lagendijk, A.K., Powell, J., Smith, K.A., Okuda, K.S., Koltowska, K., Hogan, B.M. (2023) Single-cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development. The EMBO journal. 42(11):e112590
- O'Brown, N.M., Patel, N.B., Hartmann, U., Klein, A.M., Gu, C., Megason, S.G. (2023) The secreted neuronal signal spock1 promotes blood-brain barrier development. Developmental Cell. 58(17):1534-1547.e6
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Gao, P., Jia, D., Li, P., Huang, Y., Hu, H., Sun, K., Lv, Y., Chen, X., Han, Y., Zhang, Z., Ren, X., Wang, Q., Liu, F., Tang, Z., Liu, M. (2022) Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Investigative ophthalmology & visual science. 63:32
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Blanc, M., Antczak, P., Cousin, X., Grunau, C., Scherbak, N., Rüegg, J., Keiter, S.H. (2021) The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio). The Science of the total environment. 779:146404
- Guo, W., Lei, L., Shi, X., Li, R., Wang, Q., Han, J., Yang, L., Chen, L., Zhou, B. (2021) Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant. Environmental science & technology. 55(10):6926-6935
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