Gene

gle1

ID

ZDB-GENE-040831-4

Name

GLE1 RNA export mediator

Symbol

gle1 Nomenclature History

Previous Names

gle1l (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable inositol hexakisphosphate binding activity; phospholipid binding activity; and translation initiation factor binding activity. Involved in Schwann cell development and regulation of cilium beat frequency involved in ciliary motility. Acts upstream of or within several processes, including epithelial cilium movement involved in determination of left/right asymmetry; neurogenesis; and poly(A)+ mRNA export from nucleus. Predicted to be located in nucleus. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasm. Is expressed in several structures, including head; intestine; pectoral fin; pectoral fin bud; and trunk musculature. Used to study lethal congenital contracture syndrome 1. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 23 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gle1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lethal congenital contracture syndrome 1	Alliance	Lethal congenital contracture syndrome 1	253310
		Congenital arthrogryposis with anterior horn cell disease	611890

Associated With gle1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
lethal congenital contracture syndrome 1	gle1^{hi4161aTg/hi4161aTg} (TL)	standard conditions	Seytanoglu et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR012476	mRNA export factor GLE1-like
Homologous_superfamily	IPR038506	GLE1-like superfamily

Domain Details Per Protein

Protein	Length	GLE1-like superfamily	mRNA export factor GLE1-like
UniProtKB:B0S5C8 InterPro	694
UniProtKB:B0S5D2 InterPro	717
UniProtKB:Q6DRB1 InterPro	695

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gle1-201 (1) Ensembl	Ensembl	2,637 nt	Select Tool ZFIN BLAST
mRNA	gle1-202 (1) Ensembl	Ensembl	2,186 nt	Select Tool ZFIN BLAST
ncRNA	gle1-002 (1) Ensembl	Ensembl	387 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations