Gene

rfc4

ID

ZDB-GENE-040824-3

Name

replication factor C (activator 1) 4

Symbol

rfc4 Nomenclature History

Previous Names

zgc:64030

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to contribute to DNA clamp loader activity. Involved in retina development in camera-type eye. Predicted to localize to DNA replication factor C complex and nucleus. Is expressed in alar plate midbrain region; immature eye; and nervous system. Orthologous to human RFC4 (replication factor C subunit 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64030 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rfc4 Human Ortholog

No data available

Associated With rfc4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR013748	Replication factor C, C-terminal
Domain	IPR047854	Replication factor C, lid domain
Family	IPR050238	DNA Replication and Repair Clamp Loader Complex
Homologous_superfamily	IPR008921	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	ATPase, AAA-type, core	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal	DNA Replication and Repair Clamp Loader Complex	P-loop containing nucleoside triphosphate hydrolase	Replication factor C, C-terminal	Replication factor C, lid domain
UniProtKB:Q6DRF4 InterPro	358

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	rfc4-205 (1) Ensembl	Ensembl	638 nt	Select Tool
mRNA	rfc4-201 (1) Ensembl	Ensembl	609 nt	Select Tool ZFIN BLAST
mRNA	rfc4-202 (1) Ensembl	Ensembl	1,077 nt	Select Tool ZFIN BLAST
mRNA	rfc4-203 (1) Ensembl	Ensembl	809 nt	Select Tool
mRNA	rfc4-204 (1) Ensembl	Ensembl	305 nt	Select Tool
mRNA	rfc4-206 (1) Ensembl	Ensembl	811 nt	Select Tool
mRNA	rfc4-207 (1) Ensembl	Ensembl	1,622 nt	Select Tool
mRNA	rfc4-208 (1) Ensembl	Ensembl	441 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations