Gene
myo6a
- ID
- ZDB-GENE-040819-2
- Name
- myosin VIa
- Symbol
- myo6a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in angioblast cell migration from lateral mesoderm to midline and artery morphogenesis. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Is expressed in dorsal aorta; neural tube; posterior cardinal vein; and somite. Orthologous to human MYO6 (myosin VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22 | 606346 |
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy | 606346 |
| autosomal recessive nonsyndromic deafness 37 | Alliance | Deafness, autosomal recessive 37 | 607821 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Domain | IPR032412 | Myosin VI, cargo binding domain |
| Domain | IPR036114 | Class VI myosin, motor domain |
| Domain | IPR049016 | Myosin VI, lever arm |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class VI myosin, motor domain | Kinesin motor domain superfamily | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin VI, cargo binding domain | Myosin VI, lever arm | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B757
|
1278 | |||||||
|
UniProtKB:A0A8M9PBP4
|
1150 | |||||||
|
UniProtKB:F1Q6Q6
|
1253 | |||||||
|
UniProtKB:A0A8M9P2J2
|
1153 | |||||||
|
UniProtKB:A0A8M3AL94
|
1281 | |||||||
|
UniProtKB:A0A8M3AVX0
|
1268 | |||||||
|
UniProtKB:A0A8M9PH95
|
1288 | |||||||
|
UniProtKB:A0A8M3ASY2
|
1256 |
Interactions and Pathways
No data available
Plasmids
No data available