Gene
myo6a
- ID
- ZDB-GENE-040819-2
- Name
- myosin VIa
- Symbol
- myo6a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within blood vessel morphogenesis; inner ear development; and response to auditory stimulus. Predicted to be located in several cellular components, including clathrin-coated pit; filopodium; and ruffle membrane. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; endocytic vesicle; and ruffle. Is expressed in dorsal aorta; neural tube; posterior cardinal vein; and somite. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22 | 606346 |
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy | 606346 |
| autosomal recessive nonsyndromic deafness 37 | Alliance | Deafness, autosomal recessive 37 | 607821 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Domain | IPR032412 | Myosin VI, cargo binding domain |
| Domain | IPR036114 | Class VI myosin, motor domain |
| Domain | IPR049016 | Myosin VI, lever arm |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class VI myosin, motor domain | Kinesin motor domain superfamily | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin VI, cargo binding domain | Myosin VI, lever arm | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B757
|
1278 | |||||||
|
UniProtKB:A0A8M9PBP4
|
1150 | |||||||
|
UniProtKB:F1Q6Q6
|
1253 | |||||||
|
UniProtKB:A0A8M9P2J2
|
1153 | |||||||
|
UniProtKB:A0A8M3AL94
|
1281 | |||||||
|
UniProtKB:A0A8M3AVX0
|
1268 | |||||||
|
UniProtKB:A0A8M9PH95
|
1288 | |||||||
|
UniProtKB:A0A8M3ASY2
|
1256 |
Interactions and Pathways
No data available
Plasmids
No data available