Gene
ndufv1
- ID
- ZDB-GENE-040808-73
- Name
- NADH:ubiquinone oxidoreductase core subunit V1
- Symbol
- ndufv1 Nomenclature History
- Previous Names
-
- wu:fc01f01
- wu:fc12f12
- zgc:86620
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and coenzyme binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to localize to mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in mitochondrial complex I deficiency. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; optic tectum; and pronephric duct. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6892746 (1 image)
- IMAGE:7157113 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nuclear type mitochondrial complex I deficiency 4 | Alliance | Mitochondrial complex I deficiency, nuclear type 4 | 618225 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001949 | NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site |
| Domain | IPR011538 | NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain |
| Domain | IPR019575 | NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain |
| Family | IPR011537 | NADH ubiquinone oxidoreductase, F subunit |
| Family | IPR050837 | Complex I 51 kDa subunit |
| Homologous_superfamily | IPR037207 | NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily |
| Homologous_superfamily | IPR037225 | NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Complex I 51 kDa subunit | NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site | NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain | NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily | NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain | NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily | NADH ubiquinone oxidoreductase, F subunit |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6AZA2
|
492 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndufv1-201
(1)
|
Ensembl | 1,915 nt | ||
| ncRNA |
ndufv1-003
(1)
|
Ensembl | 1,310 nt |
Interactions and Pathways
No data available
Plasmids
No data available