Gene
neu3.2
- ID
- ZDB-GENE-040801-262
- Name
- sialidase 3 (membrane sialidase), tandem duplicate 2
- Symbol
- neu3.2 Nomenclature History
- Previous Names
-
- im:6912336
- zgc:100806
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables exo-alpha-sialidase activity. Predicted to be involved in ganglioside catabolic process and oligosaccharide catabolic process. Predicted to act upstream of or within lipid catabolic process. Located in cytosol. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human NEU3 (neuraminidase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912336 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sialidase | Sialidase family | Sialidase superfamily |
|---|---|---|---|---|
|
UniProtKB:Q4V9A4
|
376 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
neu3.2-201
(1)
|
Ensembl | 1,505 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-82A9 | ZFIN Curated Data | |
| Contained in | BAC | CH73-149B22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-11J5 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6912336 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100806 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113881 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173813 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003644 (1) | 1470 nt | ||
| Genomic | GenBank:BX005026 (1) | 154034 nt | ||
| Polypeptide | UniProtKB:Q4V9A4 (1) | 376 aa |
- Lorenzo-Orts, L., Strobl, M., Steinmetz, B., Leesch, F., Pribitzer, C., Roehsner, J., Schutzbier, M., Dürnberger, G., Pauli, A. (2023) eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs. EMBO reports. 25(1):404-427
- Zizioli, D., Codenotti, S., Benaglia, G., Manzoni, M., Massardi, E., Fanzani, A., Borsani, G., Monti, E. (2023) Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development. International Journal of Molecular Sciences. 24(17):
- Okada, K., Takase, R., Hamaoka, Y., Honda, A., Ikeda, A., Hokazono, Y., Maeda, Y., Hayasaka, O., Kotani, T., Komatsu, M., Shiozaki, K. (2020) Establishment and characterization of Neu1-knockout zebrafish and its abnormal clinical phenotypes. The Biochemical journal. 477(15):2841-2857
- Shiozaki, K., Uezono, K., Hirai, G., Honda, A., Minoda, M., Wakata, R. (2020) Identification of novel fish sialidase genes responsible for KDN-cleaving activity. Glycoconjugate journal. 37(6):745-753
- Yamakawa, N., Vanbeselaere, J., Chang, L.Y., Yu, S.Y., Ducrocq, L., Harduin-Lepers, A., Kurata, J., Aoki-Kinoshita, K.F., Sato, C., Khoo, K.H., Kitajima, K., Guerardel, Y. (2018) Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nature communications. 9:4647
- Shiozaki, K., Takeshita, K., Ikeda, M., Ikeda, A., Harasaki, Y., Komatsu, M., Yamada, S., Yamaguchi, K., and Miyagi, T. (2013) Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes). Biochimie. 95(2):280-289
- Manzoni, M., Colombi, P., Papini, N., Rubaga, L., Tiso, N., Preti, A., Venerando, B., Tettamanti, G., Bresciani, R., Argenton, F., Borsani, G., and Monti, E. (2007) Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). The Biochemical journal. 408(3):395-406
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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