Gene
rab18b
- ID
- ZDB-GENE-040801-185
- Name
- RAB18B, member RAS oncogene family
- Symbol
- rab18b Nomenclature History
- Previous Names
-
- zgc:92523
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity. Involved in brain development and eye development. Acts upstream of or within chordate embryonic development. Predicted to be located in lipid droplet. Predicted to be active in Golgi apparatus. Is expressed in brain; heart tube; optic cup; retina; and retinal inner nuclear layer. Human ortholog(s) of this gene implicated in Warburg micro syndrome 3. Orthologous to human RAB18 (RAB18, member RAS oncogene family).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Bem et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Bem et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rab18b | N/A | Bem et al., 2011 |
| MO2-rab18b | N/A | Bem et al., 2011 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Warburg micro syndrome 3 | Alliance | Warburg micro syndrome 3 | 614222 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR025662 | Sigma-54 interaction domain, ATP-binding site 1 |
| Domain | IPR005225 | Small GTP-binding domain |
| Family | IPR001806 | Small GTPase |
| Family | IPR050227 | Ras-related protein Rab |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Ras-related protein Rab | Sigma-54 interaction domain, ATP-binding site 1 | Small GTPase | Small GTP-binding domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6DHC1
|
205 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rab18b-201
(1)
|
Ensembl | 1,805 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-844F9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92523 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003449 (1) | 1735 nt | ||
| Genomic | GenBank:CU694527 (2) | 38763 nt | ||
| Polypeptide | UniProtKB:Q6DHC1 (1) | 205 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hall, T.E., Martel, N., Lo, H.P., Xiong, Z., Parton, R.G. (2017) A plasmid library of full-length zebrafish rab proteins for in vivo cell biology.. Cellular logistics. 7:e1301151
- Lai, K.P., Li, J.W., Hsu, C.H., You, M.S., Chan, T.F., Tse, W.K.F., Jiang, Y.J. (2017) Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish.. Gene. 642:51-57
- Hsu, C.H., Lin, J.S., Lai, K.P., Li, J.W., Chan, T.F., You, M.S., Tse, W.K., Jiang, Y.J. (2015) A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect.. Scientific Reports. 5:10673
- Bem, D., Yoshimura, S., Nunes-Bastos, R., Bond, F.F., Kurian, M.A., Rahman, F., Handley, M.T., Hadzhiev, Y., Masood, I., Straatman-Iwanowska, A.A., Cullinane, A.R., McNeill, A., Pasha, S.S., Kirby, G.A., Foster, K., Ahmed, Z., Morton, J.E., Williams, D., Graham, J.M., Dobyns, W.B., Burglen, L., Ainsworth, J.R., Gissen, P., Muller, F., Maher, E.R., Barr, F.A., and Aligianis, I.A. (2011) Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome. American journal of human genetics. 88(4):499-507
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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