Gene
amy2al2
- ID
- ZDB-GENE-040801-179
- Name
- amylase alpha 2A-like 2
- Symbol
- amy2al2 Nomenclature History
- Previous Names
-
- zgc:92137 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable alpha-amylase activity and metal ion binding activity. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in extracellular space. Orthologous to human AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Scheldeman et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9334 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11021 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19184 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19185 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42986 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006047 | Glycosyl hydrolase, family 13, catalytic domain |
| Domain | IPR006048 | Alpha-amylase/branching enzyme, C-terminal all beta |
| Domain | IPR031319 | Alpha-amylase, C-terminal domain |
| Family | IPR006046 | Alpha amylase |
| Homologous_superfamily | IPR013780 | Glycosyl hydrolase, all-beta |
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Domain Details Per Protein
| Protein | Length | Alpha amylase | Alpha-amylase/branching enzyme, C-terminal all beta | Alpha-amylase, C-terminal domain | Glycoside hydrolase superfamily | Glycosyl hydrolase, all-beta | Glycosyl hydrolase, family 13, catalytic domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DHR7
|
512 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zgc:92137-201
(1)
|
Ensembl | 1,667 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-156J6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92137 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003729 (1) | 1615 nt | ||
| Genomic | GenBank:CU929227 (2) | 89881 nt | ||
| Polypeptide | UniProtKB:Q6DHR7 (1) | 512 aa |
No data available
- Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mohseny, A.B., Xiao, W., Carvalho, R., Spaink, H.P., Hogendoorn, P.C., and Cleton-Jansen, AM. (2012) An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. The Journal of pathology. 227(2):245-253
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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