Gene

dpm1

ID

ZDB-GENE-040801-115

Name

dolichyl-phosphate mannosyltransferase subunit 1, catalytic

Symbol

dpm1 Nomenclature History

Previous Names

zgc:101018

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have dolichyl-phosphate beta-D-mannosyltransferase activity and dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in muscle structure development. Predicted to localize to endoplasmic reticulum membrane. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Is expressed in brain; cloaca; pronephric duct; solid lens vesicle; and vertical myoseptum. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7137664 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dpm1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital disorder of glycosylation Ie	Alliance	Congenital disorder of glycosylation, type Ie	608799

Associated With dpm1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital disorder of glycosylation type I	AB + MO3-dpm1	standard conditions	Ardiccioni et al., 2016
congenital disorder of glycosylation type I	AB + MO4-dpm1	standard conditions	Ardiccioni et al., 2016