Gene
suv39h1a
- ID
- ZDB-GENE-040801-111
- Name
- SUV39H1 histone lysine methyltransferase a
- Symbol
- suv39h1a Nomenclature History
- Previous Names
-
- suv39h1
- fe02c04
- wu:fe02c04
- zgc:101027
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K9 methyltransferase activity. Acts upstream of or within exocrine pancreas development; histone H3-K9 methylation; and retina morphogenesis in camera-type eye. Predicted to be located in chromosome, centromeric region. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; digestive system; head; integument; and trunk musculature. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908410 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chromo/chromo shadow domain | Chromo domain | Chromo domain, conserved site | Chromo-like domain superfamily | Histone-lysine N-methyltransferase, H3 Lys-9 specific | Histone-lysine N-methyltransferase SUV39H1/2-like | Post-SET domain | Pre-SET domain | SET domain | SET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DGD3
|
411 | ||||||||||
|
UniProtKB:A0A8M2BEH8
|
285 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
suv39h1a-201
(1)
|
Ensembl | 1,456 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16N15 | ZFIN Curated Data | |
| Encodes | EST | fe02c04 | ||
| Encodes | EST | IMAGE:6908410 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:101027 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003592 (1) | 1414 nt | ||
| Genomic | GenBank:BX005340 (1) | 119181 nt | ||
| Polypeptide | UniProtKB:Q6DGD3 (1) | 411 aa |
- Despic, V., Dejung, M., Gu, M., Krishnan, J., Zhang, J., Herzel, L., Straube, K., Gerstein, M.B., Butter, F., Neugebauer, K.M. (2017) Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Genome research. 27(7):1184-1194
- Brocal, I., White, R.J., Dooley, C.M., Carruthers, S.N., Clark, R., Hall, A., Busch-Nentwich, E.M., Stemple, D.L., Kettleborough, R.N. (2016) Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. BMC Genomics. 17:259
- Mishima, Y., Tomari, Y. (2016) Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish. Molecular Cell. 61:874-885
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Rai, K., Jafri, I.F., Chidester, S., James, S.R., Karpf, A.R., Cairns, B.R., and Jones, D.A. (2010) Dnmt3 and G9a cooperate for tissue-specific development in zebrafish. The Journal of biological chemistry. 285(6):4110-4121
- Sun, X.J., Xu, P.F., Zhou, T., Hu, M., Fu, C.T., Zhang, Y., Jin, Y., Chen, Y., Chen, S.J., Huang, Q.H., Liu, T.X., and Chen, Z. (2008) Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. PLoS One. 3(1):e1499
- Rai, K., Nadauld, L.D., Chidester, S., Manos, E.J., James, S.R., Karpf, A.R., Cairns, B.R., and Jones, D.A. (2006) Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Molecular and cellular biology. 26(19):7077-7085
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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