Gene

tln2a

ID

ZDB-GENE-040724-263

Name

talin 2a

Symbol

tln2a Nomenclature History

Previous Names

tln1l (1)
tln2
si:busm1-132m23.1 (1)
zgc:152648 (1)
zgc:63613 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity and clathrin binding activity. Predicted to be involved in cell adhesion; cytoskeletal anchoring at plasma membrane; and endocytosis. Predicted to localize to several cellular components, including cytoskeleton; focal adhesion; and ruffle. Is expressed in brain; ectoderm; head; paraxial mesoderm; and somite. Orthologous to human TLN2 (talin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Wu et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tln2a Human Ortholog

No data available

Associated With tln2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000299	FERM domain
Domain	IPR002404	IRS-type PTB domain
Domain	IPR002558	I/LWEQ domain
Domain	IPR015009	Vinculin-binding site-containing domain
Domain	IPR015224	Talin, central
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR032425	Talin, N-terminal F0 domain
Domain	IPR037438	Talin-1/2, rod-segment
Domain	IPR049108	Talin, R4 domain
Domain	IPR054060	Talin 1-like, rod-segment domain
Domain	IPR054082	Talin, IBS2B domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR035964	I/LWEQ domain superfamily
Homologous_superfamily	IPR036476	Talin, central domain superfamily
Homologous_superfamily	IPR036723	Alpha-catenin/vinculin-like superfamily

Domain Details Per Protein

Protein	Length	Alpha-catenin/vinculin-like superfamily	Band 4.1 domain	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM conserved site	FERM domain	FERM superfamily, second domain	I/LWEQ domain	I/LWEQ domain superfamily	IRS-type PTB domain	PH-like domain superfamily	Talin-1/2, rod-segment	Talin 1-like, rod-segment domain	Talin, central	Talin, central domain superfamily	Talin, IBS2B domain	Talin, N-terminal F0 domain	Talin, R4 domain	Ubiquitin-like domain superfamily	Vinculin-binding site-containing domain
UniProtKB:A0A8M6Z7P4 InterPro	2548
UniProtKB:A0A8M2BG54 InterPro	2545
UniProtKB:A0A0R4IIA7 InterPro	2543

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tln2a-001 (1)	Havana	6,769 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tln2a-201 (1) Ensembl	Ensembl	733 nt	Select Tool
mRNA	tln2a-202 (1) Ensembl	Ensembl	9,474 nt	Select Tool
mRNA	tln2a-203 (1) Ensembl	Ensembl	7,632 nt	Select Tool ZFIN BLAST
mRNA	tln2a-204 (1) Ensembl	Ensembl	359 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations