Gene
galca
- ID
- ZDB-GENE-040724-243
- Name
- galactosylceramidase a
- Symbol
- galca Nomenclature History
- Previous Names
-
- si:ch211-199l3.4 (1)
- zgc:92561
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Exhibits galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Localizes to lysosome. Human ortholog(s) of this gene implicated in Krabbe disease. Is expressed in central nervous system and yolk syncytial layer. Orthologous to human GALC (galactosylceramidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92561 (4 images)
- IMAGE:6896288 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Krabbe disease | Alliance | Krabbe disease | 245200 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR035394 | Glycosyl hydrolase family 59, central domain |
| Domain | IPR049161 | Glycosyl hydrolase family 59, catalytic domain |
| Domain | IPR049162 | Glycosyl hydrolase family 59, C-terminal lectin domain |
| Family | IPR001286 | Glycoside hydrolase, family 59 |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Glycoside hydrolase, family 59 | Glycoside hydrolase superfamily | Glycosyl hydrolase family 59, catalytic domain | Glycosyl hydrolase family 59, central domain | Glycosyl hydrolase family 59, C-terminal lectin domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5SNX7
|
660 |
Interactions and Pathways
No data available
Plasmids
No data available