Gene

lama4

ID

ZDB-GENE-040724-213

Name

laminin, alpha 4

Symbol

lama4 Nomenclature History

Previous Names

si:busm1-189a20.2
si:dkey-119m7.3

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have signaling receptor binding activity. Involved in several processes, including endothelial cell development; muscle attachment; and notochord development. Predicted to localize to basement membrane. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Is expressed in several structures, including cardiovascular system; head; mesoderm; pectoral fin; and trunk musculature. Orthologous to human LAMA4 (laminin subunit alpha 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7160205 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lama4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1JJ	Alliance	Cardiomyopathy, dilated, 1JJ	615235

Associated With lama4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR009254	Laminin alpha, domain I
Domain	IPR010307	Laminin domain II
Family	IPR050372	Neurexin-related cell adhesion and synaptic protein
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like domain	Laminin alpha, domain I	Laminin domain II	Laminin G domain	Laminin-type EGF domain	Neurexin-related cell adhesion and synaptic protein
UniProtKB:Q2TJF5 InterPro	1871

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lama4-001 (1)	Havana	3,370 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	lama4-201 (1) Ensembl	Ensembl	6,221 nt	Select Tool
mRNA	ottdart00000004342 (1)	Havana	446 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations