Gene

arg1

ID

ZDB-GENE-040724-181

Name

arginase 1

Symbol

arg1 Nomenclature History

Previous Names

si:ch211-146f4.3 (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable arginase activity and manganese ion binding activity. Predicted to be involved in arginine catabolic process to ornithine. Predicted to act upstream of or within arginine metabolic process. Predicted to be active in cytosol. Is expressed in digestive system; eye; and reproductive system. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arg1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hyperargininemia	Alliance	Argininemia	207800

Associated With arg1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR020855	Ureohydrolase, manganese-binding site
Family	IPR006035	Ureohydrolase
Family	IPR014033	Arginase
Homologous_superfamily	IPR023696	Ureohydrolase domain superfamily