Gene
rgn
- ID
- ZDB-GENE-040718-68
- Name
- regucalcin
- Symbol
- rgn Nomenclature History
- Previous Names
-
- zgc:92078
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; gluconolactonase activity; and zinc ion binding activity. Predicted to be involved in several processes, including L-ascorbic acid biosynthetic process; cellular calcium ion homeostasis; and regulation of calcium-mediated signaling. Predicted to be located in cytoplasm and nucleus. Is expressed in intestine; kidney; and liver. Orthologous to human RGN (regucalcin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33811 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Regucalcin | Senescence marker protein-30 (SMP-30) | Six-bladed beta-propeller, TolB-like | SMP-30/Gluconolactonase/LRE-like region |
|---|---|---|---|---|---|
|
UniProtKB:Q6TLF6
|
295 | ||||
|
UniProtKB:A0A8M9QFA2
|
179 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-275D5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92078 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205746 (1) | 1475 nt | ||
| Genomic | GenBank:CU179717 (1) | 205952 nt | ||
| Polypeptide | UniProtKB:Q6TLF6 (1) | 295 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | RGN | X | Amino acid sequence comparison (1) |
- Shanaka, K.A.S.N., Jung, S., Janson, N.D., Jayasingha, J.R.P., Madushani, K.P., Kim, M.J., Lee, J. (2021) Growth and Antioxidant-Related Effects of the Reestablished Ascorbic Acid Pathway in Zebrafish (Danio rerio) by Genomic Integration of L-Gulonolactone Oxidase From Cloudy Catshark (Scyliorhinus torazame). Frontiers in Physiology. 12:685595
- Khan, A., Fahad, T.M., Akther, T., Zaman, T., Hasan, M.F., Islam Khan, M.R., Islam, M.S., Kishi, S. (2020) Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish. Journal of Cellular and Molecular Medicine. 25(2):1048-1059
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sasaki, T., Lian, S., Khan, A., Llop, J.R., Samuelson, A.V., Chen, W., Klionsky, D.J., Kishi, S. (2017) Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Autophagy. 13(2):386-403
- Sasaki, T., Lian, S., Qi, J., Bayliss, P.E., Carr, C.E., Johnson, J.L., Guha, S., Kobler, P., Catz, S.D., Gill, M., Jia, K., Klionsky, D.J., Kishi, S. (2014) Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency. PLoS Genetics. 10:e1004409
- Fujisawa, K., Terai, S., Hirose, Y., Takami, T., Yamamoto, N., and Sakaida, I. (2011) Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish. Biochemical and Biophysical Research Communications. 414(2):331-6
- Nikapitiya, C., De Zoysa, M., Kang, H.S., Oh, C., Whang, I., and Lee, J. (2008) Molecular characterization and expression analysis of regucalcin in disk abalone (Haliotis discus discus): Intramuscular calcium administration stimulates the regucalcin mRNA expression. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 150(1):117-124
- Wu, Y.D., Jiang, L., Zhou, Z., Zheng, M.H., Zhang, J., and Liang, Y. (2008) CYP1A/Regucalcin Gene Expression and Edema Formation in Zebrafish Embryos Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Bulletin of environmental contamination and toxicology. 80(6):482-486
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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