Gene

rnaseh1

ID

ZDB-GENE-040718-407

Name

ribonuclease H1

Symbol

rnaseh1 Nomenclature History

Previous Names

zgc:91971

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and RNA phosphodiester bond hydrolysis, endonucleolytic. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2. Orthologous to human RNASEH1 (ribonuclease H1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91971 (1 image)
IMAGE:7156473 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rnaseh1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2	Alliance	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2	616479

Associated With rnaseh1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002156	Ribonuclease H domain
Domain	IPR011320	Ribonuclease H1, N-terminal
Family	IPR017067	Ribonuclease H1, eukaryote
Family	IPR050092	Ribonuclease H
Homologous_superfamily	IPR009027	Large ribosomal subunit protein bL9/RNase H1, N-terminal
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily
Homologous_superfamily	IPR037056	Ribonuclease H1, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Large ribosomal subunit protein bL9/RNase H1, N-terminal	Ribonuclease H	Ribonuclease H1, eukaryote	Ribonuclease H1, N-terminal	Ribonuclease H1, N-terminal domain superfamily	Ribonuclease H domain	Ribonuclease H-like superfamily	Ribonuclease H superfamily
UniProtKB:A0A8M1N0V4 InterPro	297
UniProtKB:Q6DG94 InterPro	276

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rnaseh1-201 (1) Ensembl	Ensembl	1,281 nt	Select Tool
mRNA	rnaseh1-202 (1) Ensembl	Ensembl	835 nt	Select Tool
mRNA	rnaseh1-204 (1) Ensembl	Ensembl	1,117 nt	Select Tool ZFIN BLAST
ncRNA	rnaseh1-003 (1) Ensembl	Ensembl	535 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations