Gene

ada

ID

ZDB-GENE-040718-393

Name

adenosine deaminase

Symbol

ada Nomenclature History

Previous Names

ada1 (1)
zgc:92028

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Exhibits adenosine deaminase activity. Predicted to be involved in adenosine catabolic process; hypoxanthine salvage; and inosine biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in adenosine deaminase deficiency; asthma; and severe combined immunodeficiency. Is expressed in several structures, including digestive system; gill; heart; kidney; and muscle. Orthologous to human ADA (adenosine deaminase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6911877 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ada Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
adenosine deaminase deficiency	Alliance	Adenosine deaminase deficiency, partial	102700
adenosine deaminase deficiency	Alliance	Severe combined immunodeficiency due to ADA deficiency	102700

Associated With ada Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR006650	Adenosine/AMP deaminase active site
Domain	IPR001365	Adenosine deaminase domain
Family	IPR006330	Adenosine/adenine deaminase
Family	IPR028893	Adenosine deaminase
Homologous_superfamily	IPR032466	Metal-dependent hydrolase