Gene
syn2a
- ID
- ZDB-GENE-040718-341
- Name
- synapsin IIa
- Symbol
- syn2a Nomenclature History
- Previous Names
-
- syn2
- zgc:92311
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity. Predicted to be involved in neurotransmitter secretion. Predicted to be located in synaptic vesicle. Predicted to be active in synaptic vesicle membrane. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10915 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ATP-grasp fold, subdomain 1 | Pre-ATP-grasp domain superfamily | Synapsin | Synapsin, ATP-binding domain | Synapsin, phosphorylation site | Synapsin, pre-ATP-grasp domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R0A8
|
463 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-264N4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92311 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002597 (1) | 2178 nt | ||
| Genomic | GenBank:CU468010 (1) | 36389 nt | ||
| Polypeptide | UniProtKB:F1R0A8 (1) | 463 aa |
- Haridevamuthu, B., Manjunathan, T., Guru, A., Ranjith Wilson Alphonse, C., Boopathi, S., Murugan, R., Gatasheh, M.K., Atef Hatamleh, A., Juliet, A., Gopinath, P., Arockiaraj, J. (2022) Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae. Brain research. 1788:147941
- Kantha, P., Liu, S.T., Horng, J.L., Lin, L.Y. (2022) Acute exposure to polystyrene nanoplastics impairs skin cells and ion regulation in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 248:106203
- Wang, H., Wang, X., Jia, J., Qin, Y., Chen, S., Wang, S., Martyniuk, C.J., Bing, Y. (2022) Comparative toxicity of [C8mim]Br and [C8py]Br in early developmental stages of zebrafish (Danio rerio) with focus on oxidative stress, apoptosis, and neurotoxicity. Environmental Toxicology and Pharmacology. 92:103864
- Xu, Y., Liu, J., Tian, Y., Wang, Z., Song, Z., Li, K., Zhang, S., Zhao, H. (2022) Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging. International Journal of Molecular Sciences. 23(19):
- Chu, S., Kwon, B.R., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). Chemosphere. 263:128176
- Gu, J., Guo, M., Huang, C., Wang, X., Zhu, Y., Wang, L., Wang, Z., Zhou, L., Fan, D., Shi, L., Ji, G. (2021) Titanium dioxide nanoparticle affects motor behavior, neurodevelopment and axonal growth in zebrafish (Danio rerio) larvae. The Science of the total environment. 754:142315
- Hu, F., Zhao, Y., Yuan, Y., Yin, L., Dong, F., Zhang, W., Chen, X. (2021) Effects of environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) on early life stages of zebrafish (Danio rerio). Environmental Toxicology and Pharmacology. 83:103600
- Lovin, L.M., Kim, S., Taylor, R.B., Scarlett, K.R., Langan, L.M., Chambliss, C.K., Chatterjee, S., Scott, J.T., Brooks, B.W. (2021) Differential influences of (±) anatoxin-a on photolocomotor behavior and gene transcription in larval zebrafish and fathead minnows. Environmental sciences Europe. 33(1):
- Ren, Q., Gao, D., Mou, L., Zhang, S., Zhang, M., Li, N., Sik, A., Jin, M., Liu, K. (2021) Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. European Journal of Pharmacology. 912:174589
- Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. (2020) Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere. 270:128611
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