Gene
nr1h4
- ID
- ZDB-GENE-040718-313
- Name
- nuclear receptor subfamily 1, group H, member 4
- Symbol
- nr1h4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Exhibits bile acid binding activity and nuclear receptor activity. Involved in regulation of transcription, DNA-templated. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Is expressed in intestinal bulb and liver. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92742 (10 images)
- MGC:110190 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Wen et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| progressive familial intrahepatic cholestasis 5 | Alliance | Cholestasis, progressive familial intrahepatic, 5 | 617049 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR044114 | Bile acid receptor, ligand binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR001728 | Thyroid hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Bile acid receptor, ligand binding domain | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BHM4
|
460 | ||||||||
|
UniProtKB:Q6DGW7
|
483 |
Interactions and Pathways
No data available
Plasmids
No data available